BASIC AND CLINICAL RESEARCH
Laboratory Investigations
The Dermatology Research Laboratory is the focus of laboratory investigation in our department. This laboratory is directed by Richard Granstein, M.D. and major research programs involve studying the regulation of immune processes within the skin and, most especially, how immunity in the skin is regulated by neuropeptides and cytokines (small proteins that provide important signals from one cell type to another). In addition, a strong interest in the mechanisms by which ultraviolet radiation alters immune responses in the skin and the role of the immune system in the host response to cutaneous malignancies exists. New programs integrating these interests with gene therapy approaches to augment host immunity against malignant tumors are being developed. These projects are funded primarily by NIH grants, but also with significant support from industry, foundations and private contributions.
Laboratory research is also carried out at the Laboratory of Investigative Dermatology at Rockefeller University under the direction of James Krueger, M.D., Ph.D. Work in this laboratory centers on investigations into the pathophysiology of psoriasis and novel approaches to therapy of that disorder. This laboratory is funded by the NIH, private foundations, industry and private individuals.
Clinical Research
The department strongly supports clinical research activities by its faculty as an important avenue for the development of new therapies for the care of our patients. Current projects involve studies on the use of gamma interferon for the treatment of keloids and atopic dermatitis, the use of the immunomodulatory agent imiquimod for therapy of warts, the use of finasteride for male-pattern alopecia and an examination of physiologic responses to stress. These projects are funded primarily by industry support.